I have the answer
I was looking for.
KEVZARA helped ease my stiffness
and joint pain. Now I can focus on
what's important to me. Even if it's
just getting ready for a day out
KEVZARA is an injectable prescription medicine called an interleukin-6 (IL-6) receptor blocker. KEVZARA is used to treat adults with moderately to severely active rheumatoid arthritis (RA) after at least one other medicine called a disease‑modifying antirheumatic drug (DMARD) has been used and did not work well or could not be tolerated.
KEVZARA is injected under the skin (subcutaneous injection) once every 2 weeks, and comes in 2 doses—200 mg/1.14 mL or 150 mg/1.14 mL. You should take KEVZARA exactly as your doctor or pharmacist has told you.
Your immune system works hard to keep your body healthy by asking proteins to fight any infection or injury that it detects. For people with RA, however, their immune system actually causes harm, because it also attacks joints and other parts of the body that are healthy. That’s why RA is called an autoimmune disorder.
KEVZARA blocks one of these proteins—the interleukin-6 (IL-6) protein. KEVZARA can reduce the pain and swollen joints that you feel with RA. It may also slow the progression of joint damage over time.
If your current treatment stops working, doesn't work as well as it used to, or if your body can't tolerate it, it may be time to consider a different approach. KEVZARA is different than most other medications because it blocks a protein known as interleukin-6 (IL-6).
KEVZARA can cause serious side effects including:
Serious Infections. KEVZARA is a prescription medicine that affects your immune system. KEVZARA can lower the ability of your immune system to fight infections. Some people have serious infections while using KEVZARA, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections.
Your healthcare provider should test you for TB before starting KEVZARA.
Your healthcare provider should monitor you closely for signs and symptoms of TB during treatment with KEVZARA.
You should not start using KEVZARA if you have any kind of infection unless your healthcare provider says it is okay. Before starting KEVZARA, tell your healthcare provider if you:
are being treated for an infection.
get a lot of infections or have infections that keep coming back.
have diabetes, HIV, or a weak immune system. People with these conditions have a higher chance of getting infections.
have TB, or have been in close contact with someone with TB.
live or have lived, or have traveled to certain parts of the country (such as the Ohio and Mississippi River valleys and the Southwest) where there is an increased chance of getting certain fungal infections (histoplasmosis, coccidioidomycosis, or blastomycosis). These infections may happen more often or become more severe if you use KEVZARA. Ask your healthcare provider if you do not know if you have lived in an area where these infections are common.
have or have had hepatitis.
After starting KEVZARA, call your healthcare provider right away if you have any symptoms of an infection.
Your healthcare provider should do blood tests before you start KEVZARA, 4 to 8 weeks after starting KEVZARA, and then every 3 months during treatment to check for:
low neutrophil count. Neutrophils are white blood cells that help the body fight off bacterial infections. A low neutrophil count is common with KEVZARA, and can be severe.
low platelet count. Platelets are blood cells that help with blood clotting and stop bleeding.
increase in certain liver function tests. An increase in certain liver function tests is common with KEVZARA, and can be severe.
Your healthcare provider may not prescribe KEVZARA if your neutrophil or platelet counts are too low, or your liver function tests are too high. Your healthcare provider may stop your KEVZARA treatment for a period of time or change your dose if needed because of changes in these blood test results. Your healthcare provider should do blood tests 4 to 8 weeks after starting KEVZARA and then every 6 months during treatment to check for an:
increase in blood cholesterol levels.
Before using KEVZARA, talk to your healthcare provider about all of your medical conditions, including if you:
Talk to your doctor if you are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed.
It is not known if KEVZARA will harm your unborn baby. Tell your doctor if you become pregnant while taking KEVZARA.
It is not known if KEVZARA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use KEVZARA.
You and your doctor should consider the potential risks and benefits of taking KEVZARA while pregnant or breastfeeding. Do not take KEVZARA while pregnant or breastfeeding without talking to your doctor first.
If you are pregnant or become pregnant while using KEVZARA, there is a
pregnancy registry for women who take KEVZARA during pregnancy. The purpose of this registry
is to collect information about your health and your baby’s health. You can talk to
your healthcare provider, contact 1‑877‑311‑8972, or go to
https://mothertobaby.org/ongoing-study/kevzara/ to enroll in this registry or get more information.
See the detailed Instructions for Use that come with your Medication Guide for instructions about the right way to give your KEVZARA injections at home. You can also view our injection training videos on this site.
Whether you’ve just been prescribed KEVZARA or have already started taking it, the KevzaraConnect® Copay Card helps eligible, commercially insured patients with their out-of-pocket treatment costs for KEVZARA.
With the copay card, eligible patients can pay as little as $0 copay per month. Maximum annual copay assistance is $15,000. This program is not valid for prescriptions covered by or submitted for reimbursement under Medicaid, Medicare, VA, DOD, TRICARE or similar federal or state programs, including any state pharmaceutical assistance program. See the full Terms and Conditions.
See the KevzaraConnect® Copay Card section to apply for the copay card, or to activate an existing KevzaraConnect® Copay Card.
With RA, you may look fine, but your immune system can mistakenly attack the healthy tissue around your joints. While we don’t know exactly what causes the immune system to go off course, it is believed to play a key role in the inflammation, pain, and joint damage of RA.
In a healthy joint, there is a thin lining of tissue known as the synovium. The synovium produces a fluid that cushions and lubricates the joint, allowing bones to move past one another with ease.
In joints with RA, the immune system attacks the synovium, causing it to become inflamed. Untreated inflammation may lead to cartilage loss and bone erosion. The joint space between bones may decrease, making it difficult for them to move past one another. Eventually, bone and joint damage may take place.
You may be familiar with the differences between common nonsteroidal pain relievers, steroids, and even traditional disease-modifying antirheumatic drugs (DMARDs). But what about biologics that treat RA?
In RA, biologics target specific parts of the immune system that fuel inflammation. While most biologics affect the immune system, each type of biologic targets a different cell or protein that contributes to the signs and symptoms of RA.
The common types of biologics and ″biologic-type″ drugs for RA are:
Interleukin-6, or IL-6, is a protein that’s produced by the white cells in your blood. Elevated IL-6 levels are potentially associated with RA.
IL-6 serves dual roles. In a healthy body, it helps activate defense mechanisms against infections and some injuries. But for people with RA, higher levels of IL-6 can actually work against the best interests of the body, because it creates constant inflammation where it’s not needed. This inflammation day after day may lead to joint damage. KEVZARA targets the effects of IL-6, potentially helping to reduce the amount of inflammation in your body, and helping to slow the damage that RA may cause.
Learning about KEVZARA
Have RA? Care for someone with RA? Start the conversation off right.
Watch what led Shirley and Shonda to talk to their doctors about KEVZARA.
Learn the basics of RA and how IL-6 may play an important role in your treatment decisions.
Just been prescribed? Here's some helpful information for those just starting their KEVZARA treatments.
If you're new to injecting, or looking for a refresher, here are step-by-step videos on the proper way to take KEVZARA.
Prefer reading over watching? Download important information and instructions on injecting KEVZARA with pen or syringe.
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